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Thesis

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families

Abstract:

Protein-protein recognition plays a central role in the surveillance of self and non-self in the mammalian immune system and ultimately in cellular survival within the organism. Two systems of fundamental importance to the immune system are the Tumour Necrosis Factor (TNF) and the T cell receptor (TCR) families.

High-throughput methods developed within the Oxford Protein Production Facility have been successfully applied to the production of members of the TNF receptor and ligand su...

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Institution:
University of Oxford
Research group:
EY Jones
Oxford college:
Oriel College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Division of Structural Biology

Contributors

Role:
Supervisor
Publication date:
2005
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:dc2e58b0-d03c-4ad4-97fa-ae812495dbd0
Local pid:
ora:11448

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