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In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand.

Abstract:

The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC(50)) values were quinine = 308 ng/mL, amodiaquine =14 ng/mL, chloroquine =50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was m...

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Publication status:
Published

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Authors


Chotivanich, K More by this author
Udomsangpetch, R More by this author
Chierakul, W More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Ruangveerayuth, R More by this author
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Journal:
The American journal of tropical medicine and hygiene
Volume:
70
Issue:
4
Pages:
395-397
Publication date:
2004-04-05
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:dc2adc43-2a75-48ae-839b-32fb45c6b8bd
Source identifiers:
28916
Local pid:
pubs:28916

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