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Linked suppression of skin graft rejection can operate through indirect recognition.

Abstract:

Adult mice can be rendered immunologically tolerant of allogeneic tissues if transplanted under cover of mAbs to CD4 and CD8. Tolerance generated in this manner is characterized by the presence of regulatory CD4+ T cells that can recruit naive T cells to become tolerant also through "infectious tolerance." Regulatory CD4+ T cells can also suppress rejection of third party transplant Ags provided they are expressed on the same graft as the tolerated Ags. This process of linked suppression can ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
161
Issue:
11
Pages:
5813-5816
Publication date:
1998-12-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:dc291ec4-3752-4f55-8633-044290c93755
Source identifiers:
2085
Local pid:
pubs:2085

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