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Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells

Abstract:

Background: Patients with heterozygous germline mutations in PTEN (phosphatase and tensin homologue deleted on chromosome 10) develop autoimmunity and lymphoid hyperplasia.

Objectives: Since regulation of the phosphoinositol-3-kinase (PI3K) pathway is critical for maintaining regulatory T cell (Treg) functions we investigate Tregs in patients with heterozygous germline PTEN mutations (PTEN harmatoma tumour syndrome, PHTS).

Methods: PHTS patient...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jaci.2016.03.059

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Allergy and Clinical Immunology Journal website
Volume:
139
Issue:
2
Pages:
607–620.e15
Publication date:
2016
DOI:
EISSN:
1097-6825
ISSN:
0091-6749
URN:
uuid:dc204bf8-c04f-4a8c-a014-1910e482b1f1
Source identifiers:
615276
Local pid:
pubs:615276

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