Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells
Background: Patients with heterozygous germline mutations in PTEN (phosphatase and tensin homologue deleted on chromosome 10) develop autoimmunity and lymphoid hyperplasia.
Objectives: Since regulation of the phosphoinositol-3-kinase (PI3K) pathway is critical for maintaining regulatory T cell (Treg) functions we investigate Tregs in patients with heterozygous germline PTEN mutations (PTEN harmatoma tumour syndrome, PHTS).
Methods: PHTS patient...Expand abstract
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- Elsevier Publisher's website
- Journal of Allergy and Clinical Immunology Journal website
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- Chen et al.
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Copyright © 2016 The Authors. Published by Elsevier Inc. on behalf of the American Academy of
Allergy, Asthma & Immunology. This is an open access article under the CC BY
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