Increased neural response to fear in patients recovered from depression: a 3T functional magnetic resonance imaging study.

Journal article

BACKGROUND: Previous imaging studies have revealed that acute major depression is characterized by altered neural responses to negative emotional stimuli. Typically, responses in limbic regions such as the amygdala are increased while activity in cortical regulatory regions such as the dorsolateral prefrontal cortex (DLPFC) is diminished. Whether these changes persist in unmedicated recovered patients is unclear. METHOD: We used functional magnetic resonance imaging to examine neural response...

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Authors: Norbury, R; Selvaraj, S; Taylor, M; Harmer, C; Cowen, P

• Publication status: Published
• Journal: Psychological medicine
• Volume: 40
• Issue: 3
• Pages: 425-432
• Publication date: 2010-03-01
• DOI: 10.1017/s0033291709990596
• EISSN: 1469-8978
• ISSN: 0033-2917
• Language: English
• Keywords: Brain; Middle Aged; Female; Analysis of Variance; Fear; Magnetic Resonance Imaging; Task Performance and Analysis; Adolescent; Emotions; Image Processing, Computer-Assisted; Prefrontal Cortex; Reaction Time; Young Adult; Humans; Brain Mapping; Depressive Disorder, Major; Facial Expression; Adult; Male; Limbic System; Amygdala