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Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1.

Abstract:

Spatial and temporal coordination of polo-like kinase 1 (Plk1) activity is necessary for mitosis and cytokinesis, and this is achieved through binding to phosphorylated docking proteins with distinct subcellular localizations. Although cyclin-dependent kinase 1 (Cdk1) creates these phosphorylated docking sites in metaphase, a general principle that explains how Plk1 activity is controlled in anaphase after Cdk1 inactivation is lacking. Here, we show that the microtubule-associated protein reg...

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Publication status:
Published

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Publisher copy:
10.1038/ncb1557

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Kopajtich, R More by this author
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Journal:
Nature cell biology
Volume:
9
Issue:
4
Pages:
436-444
Publication date:
2007-04-05
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
URN:
uuid:dbfa2e59-e85a-43bd-942f-734d73e4d4f7
Source identifiers:
196729
Local pid:
pubs:196729

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