Interleukin-1beta exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures.

Journal article

Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-induced neurodegeneration whilst high concentrations had no effect. In contrast, higher concentrations of IL-1 were strongly neuroprotective in models of combined oxygen/glucose deprivation and N-methyl-D-aspartate toxicity, but no potentiation was observed at low IL-1 concentrations. Both protective and toxic eff...

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Authors: Pringle, A; Niyadurupola, N; Johns, P; Anthony, D; Iannotti, F

• Publication status: Published
• Journal: Neuroscience letters
• Volume: 305
• Issue: 1
• Pages: 29-32
• Publication date: 2001-06-01
• DOI: 10.1016/s0304-3940(01)01795-5
• EISSN: 1872-7972
• ISSN: 0304-3940
• Language: English
• Keywords: Culture Techniques; Hippocampus; Sialoglycoproteins; Brain Ischemia; Neurons; Dose-Response Relationship, Drug; Interleukin 1 Receptor Antagonist Protein; Rats; Neuroprotective Agents; Nerve Degeneration; Osmolar Concentration; Rats, Wistar; N-Methylaspartate; Animals; Interleukin-1; Neurotoxins; Anoxia; Glucose