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Characterization of mouse two-pore channels (TPCs) in NAADP-mediated Ca(2+) signalling

Abstract:

Recent studies have identified Two-Pore Channels (TPCs) as the channels activated by NAADP. To date, most studies that characterized these channels have employed heterologous expression or overexpression systems. The research reported here has focused principally on endogenous TPC activity by using single and dual gene knockout (KO) in a mouse system and has yielded insights into TPC expression levels, subcellular localisation, NAADP binding, and channel function.

Mouse models that ...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Research group:
Antony Galione
Oxford college:
New College
Role:
Author

Contributors

Division:
MSD
Department:
Pharmacology
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:dbf87d55-4266-4fa9-9eef-5214e7f4cd01
Local pid:
ora:6761

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