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Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.

Abstract:

Base excision repair (BER) is the major cellular pathway involved in removal of endogenous/spontaneous DNA lesions. Here, we study the mechanism that controls the steady-state levels of BER enzymes in human cells. By fractionating human cell extract, we purified the E3 ubiquitin ligase Mule (ARF-BP1/HectH9) as an enzyme that can ubiquitylate DNA polymerase beta (Pol beta), the major BER DNA polymerase. We identified lysines 41, 61 and 81 as the major sites of modification and show that replac...

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Publication status:
Published

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Publisher copy:
10.1038/emboj.2009.243

Authors


Parsons, JL More by this author
Dianova, II More by this author
Edelmann, MJ More by this author
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Journal:
The EMBO journal
Volume:
28
Issue:
20
Pages:
3207-3215
Publication date:
2009-10-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:dbf2caaf-ddcb-49da-8b8c-9096e544eb56
Source identifiers:
30929
Local pid:
pubs:30929

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