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Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.

Abstract:

The HIV envelope has evolved a dense array of immunologically "self" carbohydrates that efficiently protect the virus from antibody recognition. Nonetheless, one broadly neutralising antibody, IgG1 2G12, has been shown to recognise a cluster of oligomannose glycans on the HIV-1 surface antigen gp120. Thus the self carbohydrates of HIV are now regarded as potential targets for viral neutralisation and vaccine design. Here, we show that chemical inhibition of mammalian glycoprotein synthesis, w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jmb.2007.06.027

Authors


Scanlan, CN More by this author
Ritchie, GE More by this author
Crispin, M More by this author
Harvey, DJ More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Journal of molecular biology Journal website
Volume:
372
Issue:
1
Pages:
16-22
Publication date:
2007-09-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:dbf2c3c5-a81b-42f7-9c5d-89dee9833ab7
Source identifiers:
100308
Local pid:
pubs:100308

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