Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.

Journal article

The HIV envelope has evolved a dense array of immunologically "self" carbohydrates that efficiently protect the virus from antibody recognition. Nonetheless, one broadly neutralising antibody, IgG1 2G12, has been shown to recognise a cluster of oligomannose glycans on the HIV-1 surface antigen gp120. Thus the self carbohydrates of HIV are now regarded as potential targets for viral neutralisation and vaccine design. Here, we show that chemical inhibition of mammalian glycoprotein synthesis, w...

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Authors: Scanlan, C; Ritchie, G; Baruah, K; Crispin, M; Harvey, D

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Journal of molecular biology
• Volume: 372
• Issue: 1
• Pages: 16-22
• Publication date: 2007-09-01
• DOI: 10.1016/j.jmb.2007.06.027
• EISSN: 1089-8638
• ISSN: 0022-2836
• Language: English
• Keywords: Models, Biological; Mannosidases; Humans; Carbohydrate Metabolism; Epitopes; Models, Molecular; HIV Antigens; Animals; Neutralization Tests; HIV Envelope Protein gp120; Anti-HIV Agents; Alkaloids; Polysaccharides; HIV Antibodies; HIV-1