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Epidermolysis bullosa acquisita associated with epidermal-binding circulating antibodies.

Abstract:

Epidermolysis bullosa acquisita (EBA) is a rare, immunobullous disease, characterized by circulating and tissue-bound antibodies against type VII collagen (C7) of anchoring fibrils in the cutaneous basement membrane zone. These antibodies localize to the dermal aspect of salt-split skin on indirect and direct immunofluorescence (IMF). We report two patients with clinical features of EBA, in whom circulating IgG antibodies bound to the epidermal aspect of salt-split skin. In both patients dire...

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Publication status:
Published

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Authors


Wakelin, SH More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
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Journal:
The British journal of dermatology
Volume:
136
Issue:
4
Pages:
604-609
Publication date:
1997-04-05
DOI:
EISSN:
1365-2133
ISSN:
0007-0963
URN:
uuid:dbf210aa-5cc9-4578-8ebf-dc36bd32b73b
Source identifiers:
29828
Local pid:
pubs:29828

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