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Journal article

Detection of cartilage matrix degradation by autofluorescence lifetime.

Abstract:

Cartilage is a vital organ to maintain joint function. Upon arthritis, proteolytic enzymes initiate degradation of cartilage extracellular matrix (ECM) resulting in eventual loss of joint function. However, there are only limited ways of non-invasively monitoring early chemical changes in cartilage matrix. Here we report that the autofluorescence decay profiles of cartilage tissue are significantly affected by proteolytic degradation of cartilage ECM and can be characterised by measurements o...

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Publication status:
Published

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Journal:
Matrix biology : journal of the International Society for Matrix Biology
Volume:
32
Issue:
1
Pages:
32-38
Publication date:
2013-01-05
DOI:
EISSN:
1569-1802
ISSN:
0945-053X
URN:
uuid:dbd65c6e-4900-479d-ab22-25373197694b
Source identifiers:
369908
Local pid:
pubs:369908

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