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Journal article

Potent ex vivo activity of naphthoquine and methylene blue against drug-resistant clinical isolates of Plasmodium falciparum and Plasmodium vivax

Abstract:

The 4-aminoquinoline naphthoquine (NQ) and the thiazine dye methylene blue (MB) have potent in vitro efficacies against Plasmodium falciparum, but susceptibility data for P. vivax are limited. The species- and stage-specific ex vivo activities of NQ and MB were assessed using a modified schizont maturation assay on clinical field isolates from Papua, Indonesia, where multidrug-resistant P. falciparum and P. vivax are prevalent. Both compounds were highly active against P. falciparum (median [...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.00874-15

Authors


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Funding agency for:
Price, RN
More from this funder
Funding agency for:
Price, RN
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial agents and chemotherapy Journal website
Volume:
59
Issue:
10
Pages:
6117-6124
Publication date:
2015-10-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:dbcdacb4-cc93-445a-a238-5cfd7087ee95
Source identifiers:
533654
Local pid:
pubs:533654
Language:
English

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