- Abstract:
-
The 4-aminoquinoline naphthoquine (NQ) and the thiazine dye methylene blue (MB) have potent in vitro efficacies against Plasmodium falciparum, but susceptibility data for P. vivax are limited. The species- and stage-specific ex vivo activities of NQ and MB were assessed using a modified schizont maturation assay on clinical field isolates from Papua, Indonesia, where multidrug-resistant P. falciparum and P. vivax are prevalent. Both compounds were highly active against P. falciparum (median [...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1128/aac.00874-15
-
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- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Antimicrobial agents and chemotherapy Journal website
- Volume:
- 59
- Issue:
- 10
- Pages:
- 6117-6124
- Publication date:
- 2015-10-05
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- URN:
-
uuid:dbcdacb4-cc93-445a-a238-5cfd7087ee95
- Source identifiers:
-
533654
- Local pid:
- pubs:533654
- Language:
- English
- Copyright holder:
- American Society for Microbiology
- Copyright date:
- 2015
- Notes:
- Copyright © 2015, American Society for Microbiology.
Journal article
Potent ex vivo activity of naphthoquine and methylene blue against drug-resistant clinical isolates of Plasmodium falciparum and Plasmodium vivax
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