Journal article
Modulating alternative splicing by cotranscriptional cleavage of nascent intronic RNA.
- Abstract:
-
Cotranscriptional cleavage mediated by a hammerhead ribozyme can affect alternative splicing if interposed between an exon and its intronic regulatory elements. This has been demonstrated using two different alternative splicing systems based on alpha-tropomyosin and fibronectin genes. We suggest that there is a requirement for intronic regulatory elements to be covalently attached to exons that are in turn tethered to the elongating polymerase. In the case of the alternatively spliced EDA ex...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- RNA (New York, N.Y.)
- Volume:
- 14
- Issue:
- 2
- Pages:
- 359-366
- Publication date:
- 2008-02-01
- DOI:
- EISSN:
-
1469-9001
- ISSN:
-
1355-8382
- Source identifiers:
-
18977
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:18977
- UUID:
-
uuid:dbc9ed9b-faba-40d3-b44f-467a2ccb007c
- Local pid:
- pubs:18977
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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