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Modulating alternative splicing by cotranscriptional cleavage of nascent intronic RNA.

Abstract:

Cotranscriptional cleavage mediated by a hammerhead ribozyme can affect alternative splicing if interposed between an exon and its intronic regulatory elements. This has been demonstrated using two different alternative splicing systems based on alpha-tropomyosin and fibronectin genes. We suggest that there is a requirement for intronic regulatory elements to be covalently attached to exons that are in turn tethered to the elongating polymerase. In the case of the alternatively spliced EDA ex...

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Publication status:
Published

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Publisher copy:
10.1261/rna.615508

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
RNA (New York, N.Y.)
Volume:
14
Issue:
2
Pages:
359-366
Publication date:
2008-02-05
DOI:
EISSN:
1469-9001
ISSN:
1355-8382
URN:
uuid:dbc9ed9b-faba-40d3-b44f-467a2ccb007c
Source identifiers:
18977
Local pid:
pubs:18977

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