- Abstract:
-
Cotranscriptional cleavage mediated by a hammerhead ribozyme can affect alternative splicing if interposed between an exon and its intronic regulatory elements. This has been demonstrated using two different alternative splicing systems based on alpha-tropomyosin and fibronectin genes. We suggest that there is a requirement for intronic regulatory elements to be covalently attached to exons that are in turn tethered to the elongating polymerase. In the case of the alternatively spliced EDA ex...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1261/rna.615508
-
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- Journal:
- RNA (New York, N.Y.)
- Volume:
- 14
- Issue:
- 2
- Pages:
- 359-366
- Publication date:
- 2008-02-05
- DOI:
- EISSN:
-
1469-9001
- ISSN:
-
1355-8382
- URN:
-
uuid:dbc9ed9b-faba-40d3-b44f-467a2ccb007c
- Source identifiers:
-
18977
- Local pid:
- pubs:18977
- Copyright date:
- 2008
Journal article
Modulating alternative splicing by cotranscriptional cleavage of nascent intronic RNA.
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