Prefrontal cortex cytoarchitecture in normal aging and Alzheimer's disease: a relationship with IQ.
We have previously shown that the minicolumnar spacing of neurons in the cerebral cortex relates to cognitive ability, and that minicolumn thinning occurs in old age. The present study examines further the relationship between cognitive ability and cortical fine structure (minicolumn organization and neuropathology) in the dorsolateral prefrontal cortex (dlPFC) and the parahippocampal gyrus (PHG) in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Premortem neuropsychological sco...Expand abstract
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