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Prefrontal cortex cytoarchitecture in normal aging and Alzheimer's disease: a relationship with IQ.

Abstract:

We have previously shown that the minicolumnar spacing of neurons in the cerebral cortex relates to cognitive ability, and that minicolumn thinning occurs in old age. The present study examines further the relationship between cognitive ability and cortical fine structure (minicolumn organization and neuropathology) in the dorsolateral prefrontal cortex (dlPFC) and the parahippocampal gyrus (PHG) in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Premortem neuropsychological sco...

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Publisher copy:
10.1007/s00429-012-0381-x

Authors


van Veluw, SJ More by this author
Sawyer, EK More by this author
Cousijn, H More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division
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Journal:
Brain Struct Funct
Publication date:
2012-02-03
DOI:
EISSN:
1863-2661
URN:
uuid:dbc8cf34-f7f1-431c-94f9-aaa507c52d89
Source identifiers:
246313
Local pid:
pubs:246313
Language:
English

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