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3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice

Abstract:

Caffeoylquinic acid (CQA) is a natural polyphenol with evidence of antioxidant and neuroprotective effects and prevention of deficits in spatial learning and memory. We studied the cognitive-enhancing effect of 3,4,5-tricaffeoylquinic acid (TCQA) and explored its cellular and molecular mechanism in the senescence-accelerated mouse prone 8 (SAMP8) model of aging and Alzheimer’s disease as well as in human neural stem cells (hNSCs). Mice were fed with 5 mg/kg of TCQA for 30 days and were tested...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.18632/aging.101748

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Ferdousi, F More by this author
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Publisher:
Impact Journals Publisher's website
Journal:
Aging Journal website
Volume:
11
Issue:
2
Pages:
401-422
Publication date:
2019-01-17
Acceptance date:
2018-12-26
DOI:
EISSN:
1945-4589
Pubs id:
pubs:965742
URN:
uri:dbbe6b55-1abb-417a-8d13-9807f92893db
UUID:
uuid:dbbe6b55-1abb-417a-8d13-9807f92893db
Local pid:
pubs:965742

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