Journal article icon

Journal article

C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.

Abstract:

The Ho crossed aldol condensation provides access to a series of carbon branched iminosugars as exemplified by the synthesis of enantiomeric pairs of isoDMDP, isoDGDP, and isoDAB, allowing comparison of their biological activities with three linear isomeric natural products DMDP, DGDP, and DAB and their enantiomers. L-IsoDMDP [(2S,3S,4R)-2,4-bis(hydroxymethyl)pyrrolidine-3,4-diol], prepared in 11 steps in an overall yield of 45% from d-lyxonolactone, is a potent specific competitive inhibitor...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/jo4005487

Authors


Expand authors...
Journal:
The Journal of organic chemistry
Volume:
78
Issue:
15
Pages:
7380-7397
Publication date:
2013-08-05
DOI:
EISSN:
1520-6904
ISSN:
0022-3263
URN:
uuid:dbbe2635-7179-45ae-95d2-00bc59d0c97a
Source identifiers:
401268
Local pid:
pubs:401268

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP