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The problem of subgroup analyses: an example from a trial on ruptured intracranial aneurysms.

Abstract:

The randomized ISAT demonstrated the superiority of endovascular treatment in patients with ruptured intracranial aneurysms considered suitable for either clipping or coiling. A later publication proposed a second look at the results, demonstrating that older patients with ruptured MCA aneurysms appeared to benefit from clipping, in disagreement with the general findings of the trial. Subgroup analyses in randomized trials and observational studies examine whether effects of interventions dif...

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Publication status:
Published

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Publisher copy:
10.3174/ajnr.a2442

Authors


Naggara, O More by this author
Raymond, J More by this author
Guilbert, F More by this author
Altman, DG More by this author
Journal:
AJNR. American journal of neuroradiology
Volume:
32
Issue:
4
Pages:
633-636
Publication date:
2011-04-05
DOI:
EISSN:
1936-959X
ISSN:
0195-6108
URN:
uuid:dbbbdf69-db8e-4c45-a8d6-b29d3c6dfb55
Source identifiers:
179181
Local pid:
pubs:179181

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