The problem of subgroup analyses: an example from a trial on ruptured intracranial aneurysms.

Journal article

The randomized ISAT demonstrated the superiority of endovascular treatment in patients with ruptured intracranial aneurysms considered suitable for either clipping or coiling. A later publication proposed a second look at the results, demonstrating that older patients with ruptured MCA aneurysms appeared to benefit from clipping, in disagreement with the general findings of the trial. Subgroup analyses in randomized trials and observational studies examine whether effects of interventions dif...

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Authors: Naggara, O; Raymond, J; Guilbert, F; Altman, D

• Publication status: Published
• Journal: AJNR. American journal of neuroradiology
• Volume: 32
• Issue: 4
• Pages: 633-636
• Publication date: 2011-04-01
• DOI: 10.3174/ajnr.a2442
• EISSN: 1936-959X
• ISSN: 0195-6108
• Language: English
• Keywords: Surgical Instruments; Guidelines as Topic; Embolization, Therapeutic; Humans; Intracranial Aneurysm; Randomized Controlled Trials as Topic; Aneurysm, Ruptured; Patient Selection