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Journal article

Targeting cardiac sympatho-vagal imbalance using gene transfer of nitric oxide synthase.

Abstract:

Heightened sympathetic excitation and diminished parasympathetic suppression of heart rate, cardiac contractility and vascular tone are all associated with cardiovascular diseases such as hypertension and ischemic heart disease. This phenotype often exists before these disease states have been established and is a strong correlate of mortality in the population. However, the causal role of the autonomic phenotype in the development and maintenance of hypertension and myocardial ischemia remai...

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Publication status:
Published

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Publisher copy:
10.1016/j.yjmcc.2008.12.013

Authors


Danson, EJ More by this author
Dawson, TA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
Journal of molecular and cellular cardiology
Volume:
46
Issue:
4
Pages:
482-489
Publication date:
2009-04-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:dba995c0-8a05-457a-9229-bdfee01de5cd
Source identifiers:
106430
Local pid:
pubs:106430

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