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Journal article

Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei.

Abstract:

Simian adenoviral vectors (SAd) offer an attractive alternative to standard human adenovirus serotype 5 (AdH5) subunit vaccination, due to pre-existing immunity affecting vaccine performance. We have used a mouse model of liver-stage malaria to test the efficiency of three chimpanzee-origin adenoviral vectors, AdC6, AdC7 and AdC9 containing ME.TRAP as an insert. AdC7 and AdC9 elicited strong immunogenicity ( approximately 20% of CD8(+) T cells in spleen), equivalent to or outperforming AdH5 a...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200737672

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
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Journal:
European journal of immunology
Volume:
38
Issue:
3
Pages:
732-741
Publication date:
2008-03-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:dba6ac7f-a4da-4e06-ae5a-3c465c738222
Source identifiers:
34126
Local pid:
pubs:34126

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