Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei.

Journal article

Simian adenoviral vectors (SAd) offer an attractive alternative to standard human adenovirus serotype 5 (AdH5) subunit vaccination, due to pre-existing immunity affecting vaccine performance. We have used a mouse model of liver-stage malaria to test the efficiency of three chimpanzee-origin adenoviral vectors, AdC6, AdC7 and AdC9 containing ME.TRAP as an insert. AdC7 and AdC9 elicited strong immunogenicity ( approximately 20% of CD8(+) T cells in spleen), equivalent to or outperforming AdH5 a...

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Authors: Reyes-Sandoval, A; Sridhar, S; Berthoud, T; Moore, A; Harty, J

• Publication status: Published
• Journal: European journal of immunology
• Volume: 38
• Issue: 3
• Pages: 732-741
• Publication date: 2008-03-01
• DOI: 10.1002/eji.200737672
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Animals; Adenoviruses, Simian; Interferon-gamma; Mice, Inbred BALB C; Malaria Vaccines; Mice; Epitopes, B-Lymphocyte; Antigens, CD; Survival Analysis; Mice, Inbred C57BL; CD8-Positive T-Lymphocytes; Epitopes, T-Lymphocyte; Protozoan Proteins; Spleen; Female; Genetic Vectors; Malaria; Injections, Intradermal; T-Lymphocyte Subsets; Cytokines; Plasmodium berghei; Poxviridae; Vaccines, DNA; Granzymes