- Abstract:
-
Background: Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment. Recent studies demonstrated reducing this acidity through systemic buffers significantly inhibits development and growth of metastases in mouse xenografts. Methods: We apply and extend a previously developed mathematical model of blood and tumou...
Expand abstract - Publisher copy:
- 10.1038/bjc.2012.58
-
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- Journal:
- British Journal of Cancer
- Volume:
- 106
- Issue:
- 7
- Pages:
- 1280-1287
- Publication date:
- 2012-03-27
- DOI:
- EISSN:
-
1532-1827
- ISSN:
-
0007-0920
- URN:
-
uuid:db9f5798-3351-4e95-a766-9aaef0f783d9
- Source identifiers:
-
322830
- Local pid:
- pubs:322830
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Predicting the safety and efficacy of buffer therapy to raise tumour pHe: An integrative modelling study
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