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Predicting the safety and efficacy of buffer therapy to raise tumour pHe: An integrative modelling study

Abstract:

Background: Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment. Recent studies demonstrated reducing this acidity through systemic buffers significantly inhibits development and growth of metastases in mouse xenografts. Methods: We apply and extend a previously developed mathematical model of blood and tumou...

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Publisher copy:
10.1038/bjc.2012.58

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
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Journal:
British Journal of Cancer
Volume:
106
Issue:
7
Pages:
1280-1287
Publication date:
2012-03-27
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:db9f5798-3351-4e95-a766-9aaef0f783d9
Source identifiers:
322830
Local pid:
pubs:322830
Language:
English
Keywords:

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