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Journal article

Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis.

Abstract:

Infection of mice with the intestinal bacterial pathogen Citrobacter rodentium results in colonic mucosal hyperplasia and a local Th1 inflammatory response similar to that seen in mouse models of inflammatory bowel disease. In these latter models, and in patients with Crohn's disease, neutralization of tumor necrosis factor alpha (TNF-alpha) is of therapeutic benefit. Since there is no information on the role of TNF-alpha in either immunity to noninvasive bacterial pathogens or on the role of...

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Publication status:
Published

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Authors


Gonçalves, NS More by this author
Ghaem-Maghami, M More by this author
Monteleone, G More by this author
Frankel, G More by this author
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Journal:
Infection and immunity
Volume:
69
Issue:
11
Pages:
6651-6659
Publication date:
2001-11-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:db9b3852-3a3d-4548-997f-33690caecce2
Source identifiers:
98267
Local pid:
pubs:98267

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