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Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials: combined analysis of meta-epidemiological studies.

Abstract:

BACKGROUND: The design of randomised controlled trials (RCTs) should incorporate characteristics (such as concealment of randomised allocation and blinding of participants and personnel) that avoid biases resulting from lack of comparability of the intervention and control groups. Empirical evidence suggests that the absence of such characteristics leads to biased intervention effect estimates, but the findings of different studies are not consistent. OBJECTIVES: To examine the influence of u...

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Publication status:
Published

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Publisher copy:
10.3310/hta16350

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Health technology assessment (Winchester, England)
Volume:
16
Issue:
35
Pages:
1-82
Publication date:
2012-09-05
DOI:
EISSN:
2046-4924
ISSN:
1366-5278
URN:
uuid:db987b81-a651-4de1-b4ed-9a3a4cb0b429
Source identifiers:
354782
Local pid:
pubs:354782

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