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Journal article

Combined blockade of signalling pathways shows marked anti-tumour potential in phaeochromocytoma cell lines.

Abstract:

Currently, there is no completely effective therapy available for metastatic phaeochromocytomas (PCCs) and paragangliomas. In this study, we explore new molecular targeted therapies for these tumours, using one more benign (mouse phaeochromocytoma cell (MPC)) and one more malignant (mouse tumour tissue (MTT)) mouse PCC cell line - both generated from heterozygous neurofibromin 1 knockout mice. Several PCC-promoting gene mutations have been associated with aberrant activation of PI3K/AKT, mTOR...

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Publication status:
Published

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Publisher copy:
10.1530/jme-12-0028

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Journal:
Journal of molecular endocrinology
Volume:
49
Issue:
2
Pages:
79-96
Publication date:
2012-10-01
DOI:
EISSN:
1479-6813
ISSN:
0952-5041
Source identifiers:
339878

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