Permeation of styryl dyes through nanometer-scale pores in membranes.

Journal article

Styryl dyes are widely used to study synaptic vesicle (SV) recycling in neurons; vesicles are loaded with dye during endocytosis, and dye is subsequently released via exocytosis. During putative kiss-and-run exocytosis, efflux of dye from individual SVs has been proposed to occur via two sequential steps: dissociation from the membrane followed by permeation through a small fusion pore. To improve our understanding of the kinetics of efflux of dye from vesicles during kiss-and-run events, we ...

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Authors: Wu, Y; Ma, L; Cheley, S; Bayley, H; Cui, Q

• Publication status: Published
• Journal: Biochemistry
• Volume: 50
• Issue: 35
• Pages: 7493-7502
• Publication date: 2011-09-01
• DOI: 10.1021/bi2006288
• EISSN: 1520-4995
• ISSN: 0006-2960
• Language: English
• Keywords: Quaternary Ammonium Compounds; Pyridinium Compounds; Neurotoxins; Hemolysin Proteins; Cell Membrane Permeability; Bacterial Toxins; Nanotechnology; Cell Membrane; Fluorescent Dyes; Synaptic Vesicles