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Thesis

Contribution of monocytes to immunopathology during influenza A virus infection

Abstract:

This thesis investigates the role of monocytes in mouse and human influenza A virus (IAV) infection and questions how they contribute to immunopathology. I first show in mice that Ly6Chi monocytes are dominant immune cells in the lungs during severe IAV infection. Comparison of the gene expression profiles in lungs of severe or mild IAV infection revealed enrichment of genes related to monocyte recruitment in severe disease, which were more rapidly expressed than in mild infecti...

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Institution:
University of Oxford
Oxford college:
St Edmund Hall
Department:
Medical Sciences Division - Molecular Medicine,Weatherall Institute of

Contributors

Role:
Supervisor
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Funding agency for:
Suzanne Lois Cole
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:db927890-61de-405e-8681-8f5c33f08591
Local pid:
ora:11342

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