Effects of stimulation of the subthalamic area on oscillatory pallidal activity in Parkinson's disease.

Journal article

The pattern of neuronal discharge within the basal ganglia is disturbed in Parkinson's disease (PD). In particular, there is a tendency for neuronal elements to synchronise at around 20 Hz in the absence of dopaminergic treatment, whereas this activity can be replaced by spontaneous synchronisation at much higher frequencies (>70 Hz) following dopaminergic treatment [J. Neurosci. 21 (2001) 1033; Brain 126 (2003) 2153]. In two PD patients (3 sides), we show that stimulating the subthalamic ...

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Authors: Brown, P; Mazzone, P; Oliviero, A; Altibrandi, MG; Pilato, F

• Publication status: Published
• Journal: Experimental neurology
• Volume: 188
• Issue: 2
• Pages: 480-490
• Publication date: 2004-08-01
• DOI: 10.1016/j.expneurol.2004.05.009
• EISSN: 1090-2430
• ISSN: 0014-4886
• Language: English
• Keywords: Membrane Potentials; Globus Pallidus; Middle Aged; Electrodes, Implanted; Aged; Subthalamus; Humans; Male; Parkinson Disease; Electric Stimulation Therapy; Electroencephalography; Signal Processing, Computer-Assisted; Magnetic Resonance Imaging; Synaptic Transmission; Biological Clocks; Female