Journal article icon

Journal article

Set2 methyltransferase facilitates DNA replication and promotes genotoxic stress responses through MBF-dependent transcription

Abstract:
Chromatin modification through histone H3 lysine 36 methylation by the SETD2 tumor suppressor plays a key role in maintaining genome stability. Here, we describe a role for Set2-dependent H3K36 methylation in facilitating DNA replication and the transcriptional responses to both replication stress and DNA damage through promoting
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Version of record

Actions


Access Document


Files:
Publisher copy:
10.1016/j.celrep.2017.08.058

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK-MRC Oxford Institute for Radiation Oncology
Kishkevich, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK-MRC Oxford Institute for Radiation Oncology
Keszthelyi, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK-MRC Oxford Institute for Radiation Oncology
Expand authors...
Publisher:
Elsevier (Cell Press) Publisher's website
Journal:
Cell reports Journal website
Volume:
20
Issue:
11
Pages:
2693-2705
Publication date:
2017-09-12
Acceptance date:
2017-08-17
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:729111
URN:
uri:db8d788b-ed33-44e9-bba3-8415d622fe9a
UUID:
uuid:db8d788b-ed33-44e9-bba3-8415d622fe9a
Local pid:
pubs:729111

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP