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Demonstration of the blood-stage controlled human malaria infection model to assess efficacy of the Plasmodium falciparum AMA1 vaccine FMP2.1/AS01

Abstract:

 Mosquito-bite controlled human malaria infection (CHMI) models have been widely used to assess efficacy of pre-erythrocytic vaccine candidates in small proof-of-concept Phase IIa clinical trials. Efficacy testing of blood-stage vaccines, however, has generally relied on larger-scale Phase IIb field trials in endemic populations. We report the use of a blood-stage Plasmodium falciparum CHMI model to assess blood-stage vaccine candidates using impact on the parasite multiplication rate (PMR) a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/infdis/jiw039

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Funding agency for:
Douglas, AD
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Funding agency for:
Hodgson, SH
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Publisher:
Oxford University Press Publisher's website
Journal:
The Journal of infectious diseases Journal website
Publication date:
2016-01-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:db7d7d91-4730-4b51-a051-6d920a879a56
Source identifiers:
608971
Local pid:
pubs:608971
Language:
English
Keywords:

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