Journal article
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
- Abstract:
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Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10−8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/s41588-024-01714-w
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Bibliographic Details
- Publisher:
- Nature Research
- Journal:
- Nature Genetics More from this journal
- Volume:
- 56
- Issue:
- 5
- Pages:
- 778-791
- Publication date:
- 2024-04-30
- Acceptance date:
- 2024-03-11
- DOI:
- EISSN:
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1546-1718
- ISSN:
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1061-4036
Item Description
- Language:
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English
- Source identifiers:
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1970064
- Deposit date:
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2024-07-20
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