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Protein crowding and lipid complexity influence the nanoscale dynamic organization of ion channels in cell membranes

Abstract:

Cell membranes are crowded and complex environments. To investigate the effect of protein-lipid interactions on dynamic organization in mammalian cell membranes, we have performed coarsegrained molecular dynamics simulations containing >100 copies of an inwardly rectifying potassium (Kir) channel which forms specific interactions with the regulatory lipid phosphatidylinositol 4,5-bisphosphate (PIP2). The tendency of protein molecules to cluster has the effect of organizing th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-16865-6

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
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Engineering and Physical Sciences Research Council More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
16647
Publication date:
2017-11-30
Acceptance date:
2017-11-15
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:747093
URN:
uri:db7bd104-7e77-4303-8d6d-47fb0fa063fe
UUID:
uuid:db7bd104-7e77-4303-8d6d-47fb0fa063fe
Local pid:
pubs:747093

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