Interleukin-1beta -induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study.

Journal article

The cytokine interleukin-1beta (IL-1beta) is implicated in a broad spectrum of CNS pathologies, in which it is thought to exacerbate neuronal loss. Here, the effects of injecting recombinant rat IL-1beta into the striatum of 3-week-old rats were followed noninvasively from 2 to 123 hr using magnetic resonance imaging and spectroscopy. Four hours after injection of IL-1beta (1 ng in 1 microliter), cerebral blood volume was significantly increased, the blood-brain barrier (BBB) became permeable...

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Authors: Blamire, A; Anthony, D; Rajagopalan, B; Sibson, N; Perry, V

• Publication status: Published
• Journal: Journal of neuroscience : the official journal of the Society for Neuroscience
• Volume: 20
• Issue: 21
• Pages: 8153-8159
• Publication date: 2000-11-01
• EISSN: 1529-2401
• ISSN: 0270-6474
• Language: English
• Keywords: Cerebrovascular Circulation; Immune Sera; Cell Count; Contrast Media; Corpus Striatum; Magnetic Resonance Imaging; Neutrophil Infiltration; Brain; Rats; Acute Disease; Capillary Permeability; Recombinant Proteins; Rats, Wistar; Blood-Brain Barrier; Animals; Interleukin-1; Encephalitis; Chronic Disease; Disease Models, Animal; Blood Volume; Microinjections; Diffusion