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Locating macromolecules and determining structures inside bacterial cells using electron cryotomography

Abstract:

Electron cryotomography (cryo-ET) is an imaging technique uniquely suited to the study of bacterial ultrastructure and cell biology. Recent years have seen a surge in structural and cell biology research on bacteria using cryo-ET. This research has driven major technical developments in the field, with applications emerging to address a wide range of biological questions. In this review, we explore the diversity of cryo-ET approaches used for structural and cellular microbiology, with a focus...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbapap.2018.06.003

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0002-0168-0277
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Funding agency for:
Bharat, T
Grant:
202231/Z/16/Z
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Funding agency for:
Melia, C
Grant:
GN2634
Publisher:
Elsevier Publisher's website
Journal:
Biochimica et Biophysica Acta Journal website
Volume:
1866
Issue:
9
Pages:
973-981
Publication date:
2018-06-13
Acceptance date:
2018-06-11
DOI:
ISSN:
0006-3002
Pmid:
29908328
Language:
English
Keywords:
Pubs id:
pubs:858926
UUID:
uuid:db79dba1-f6bd-407c-8a52-ff92323bccec
Local pid:
pubs:858926
Deposit date:
2018-07-11

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