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Journal article

Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer.

Abstract:

Forkhead box O3 (FOXO3) has a wide range of functions: it promotes tumor suppression, cell cycle arrest, repair of damaged DNA, detoxification of reactive oxygen species, apoptosis and plays a pivotal role in promoting longevity. FOXO3 is a key downstream target of the PI3K-Akt pathway in response to cellular stimulation by growth factors or insulin and has been proposed as a bridge between ageing and tumor suppression. Three SNPs in the FOXO3 gene (rs3800231, rs9400239 and rs479744) that hav...

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Publication status:
Published

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Publisher copy:
10.3892/or.2011.1359

Authors


Hüsing, A More by this author
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Journal:
Oncology reports
Volume:
26
Issue:
4
Pages:
979-986
Publication date:
2011-10-05
DOI:
EISSN:
1791-2431
ISSN:
1021-335X
URN:
uuid:db782834-60c6-42d0-a45b-d066db3679d6
Source identifiers:
172423
Local pid:
pubs:172423

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