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Analysis of T-cell receptor usage in activated T-cell clones from Hashimoto's thyroiditis and Graves' disease.

Abstract:

Rearrangements to the T-cell receptor (TcR) beta and gamma gene loci were studied in T cells derived from the thyroid glands of a patient with Hashimoto's (HT) and another with Graves' (GD) autoimmune thyroiditis. The cells studied were freshly isolated mononuclear cells, T-cell lines grown in the presence of anti-CD3 and IL-2 and T-cell clones. Numerous different rearrangements to the constant regions of TcR beta and TcR gamma and in the variable gene region of TcR beta were observed. These ...

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Publication status:
Published

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Authors


Lipoldova, M More by this author
Grubeck-Loebenstein, B More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Journal of autoimmunity
Volume:
2
Issue:
1
Pages:
1-13
Publication date:
1989-02-05
DOI:
EISSN:
1095-9157
ISSN:
0896-8411
URN:
uuid:db77b1c8-1534-4b32-afd8-a4015fe919b7
Source identifiers:
481772
Local pid:
pubs:481772

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