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Fitness benefits in fluoroquinolone-resistant Salmonella Typhi in the absence of antimicrobial pressure.

Abstract:

Fluoroquinolones (FQ) are the recommended antimicrobial treatment for typhoid, a severe systemic infection caused by the bacterium Salmonella enterica serovar Typhi. FQ-resistance mutations in S. Typhi have become common, hindering treatment and control efforts. Using in vitro competition experiments, we assayed the fitness of eleven isogenic S. Typhi strains with resistance mutations in the FQ target genes, gyrA and parC. In the absence of antimicrobial pressure, 6 out of 11 mutants carried ...

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Publication status:
Published online

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Publisher copy:
10.7554/eLife.01229

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
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Journal:
eLife
Volume:
2
Pages:
e01229
Publication date:
2013-01-05
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
URN:
uuid:db6ac2b3-5593-4f3c-b3f9-edee777b87a0
Source identifiers:
441790
Local pid:
pubs:441790

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