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Age-related changes in speed & mechanism of adult skeletal muscle stem cell migration

Abstract:

Skeletal muscle undergoes a progressive age-related loss in mass and function. Preservation of muscle mass depends in part on satellite cells, the resident stem cells of skeletal muscle. Reduced satellite cell function may contribute to the age-associated decrease in muscle mass. Here, we focused on characterizing the effect of age on satellite cell migration. We report that aged satellite cells migrate at less than half the speed of young cells. In addition, aged cells show abnormal membrane...

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Publication date:
2012-01-01
URN:
uuid:db6392ca-b25d-43e1-a645-3e70ab75ff08
Local pid:
oai:eprints.maths.ox.ac.uk:1514

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