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The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma, tumor necrosis factor alpha, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation.

Abstract:

Antigen presentation reactions are dependent upon the expression of the class II major histocompatibility antigens (MHC), the T-cell receptor, and the presented antigen. Recent studies demonstrate that such processes also require the presence of adhesion molecules such as lymphocyte functional antigen 1 (LFA-1) and its cell surface ligand, intercellular adhesion molecule 1 (ICAM-1). It has been suggested that the brain astrocyte can function as a facultative antigen presenting cell (APC). Thi...

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Authors


Frohman, EM More by this author
Frohman, TC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Vayuvegula, B More by this author
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Journal:
Journal of neuroimmunology
Volume:
23
Issue:
2
Pages:
117-124
Publication date:
1989-07-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:db4dd167-40d1-4573-a3fb-17df7faf8ceb
Source identifiers:
482693
Local pid:
pubs:482693

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