Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution.

Journal article

To study the evolutionary dynamics of regulatory DNA, we mapped >1.3 million deoxyribonuclease I-hypersensitive sites (DHSs) in 45 mouse cell and tissue types, and systematically compared these with human DHS maps from orthologous compartments. We found that the mouse and human genomes have undergone extensive cis-regulatory rewiring that combines branch-specific evolutionary innovation and loss with widespread repurposing of conserved DHSs to alternative cell fates, and that this process ...

Expand abstract

Authors: Vierstra, J; Rynes, E; Sandstrom, R; Zhang, M; Canfield, T

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 346
• Issue: 6212
• Pages: 1007-1012
• Publication date: 2014-11-01
• DOI: 10.1126/science.1246426
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: DNA; Evolution, Molecular; Base Sequence; Genome, Human; Transcription Factors; Restriction Mapping; Conserved Sequence; Mice; Humans; Deoxyribonuclease I; Regulatory Sequences, Nucleic Acid; Animals