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Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3

Abstract:

Most animal cells express mixtures of the three subtypes of inositol 1,4,5-trisphosphate receptor (IP3R) encoded by vertebrate genomes. Activation of each subtype by different agonists has not hitherto been examined in cells expressing defined homogenous populations of IP3R. Here we measure Ca2+

release evoked by synthetic analogues of IP3 using a Ca2+ indicator within the lumen of the endoplasmic reticulum of permeabilized DT40 ce... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0054877

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Department:
Default/Not Applicable
Potter, BVL More by this author
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Publisher:
PLoS Publisher's website
Journal:
PLoS ONE Journal website
Volume:
8
Issue:
1
Pages:
e54877
Publication date:
2013-01-22
Acceptance date:
2012-12-17
DOI:
ISSN:
1932-6203
Pubs id:
pubs:640297
URN:
uri:db4ab6af-6f96-45d1-a3b4-64127ff1169f
UUID:
db4ab6af-6f96-45d1-a3b4-64127ff1169f
Local pid:
pubs:640297

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