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Analysing the evolutionary history of HCV: puzzle of ancient phylogenetic discordance.

Abstract:

Though recombination is an important evolutionary strategy in RNA viruses, only two cases of HCV recombinant strains have been reported. Our objective was to analyze the evolutionary history of the HCV genotypes aiming to obtain evidence of significant phylogenetic discordance due to either recombination or selective forces leading to convergent/divergent evolution. The data support an evolutionary preservation of the interferon-resistance related genomic region (ISDR) for the genotypes 1 and...

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Ntziora, F More by this author
Paraskevis, D More by this author
Magiorkinis, E More by this author
Hatzakis, A More by this author
Journal:
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Volume:
7
Issue:
3
Pages:
354-360
Publication date:
2007-06-05
DOI:
EISSN:
1567-7257
ISSN:
1567-1348
URN:
uuid:db469980-d3ed-4863-b552-3982f006d3c8
Source identifiers:
270273
Local pid:
pubs:270273

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