Monoclonal antibody BRL 12 reacts with bone keratan sulphate proteoglycan.

Journal article

Our previous studies suggest that a monoclonal antibody, BRL 12, reacts with a specific product of differentiated cells of the osteoblastic lineage. In the present study, the bone constituent recognized by this antibody has been characterized by gel filtration, ion exchange chromatography, protein blotting and immunolocalization. Our findings show that the antibody reacts with an epitope associated with the core protein of rabbit keratan sulfate proteoglycan (KSPG), a molecule which shares co...

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Authors: Joyner, C; Virdi, A; Beresford, J; Bennett, J; Owen, M

• Publication status: Published
• Publisher: Informa Healthcare
• Journal: Connective tissue research
• Volume: 28
• Issue: 3
• Pages: 205-212
• Publication date: 1992-01-01
• DOI: 10.3109/03008209209015037
• EISSN: 1607-8438
• ISSN: 0300-8207
• Language: English
• Keywords: Cornea; Animals; Bone and Bones; Antibodies, Monoclonal; Binding Sites, Antibody; Keratan Sulfate; Rabbits; Antigen-Antibody Reactions