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Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans.

Abstract:

Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries. In analogy to other crowd diseases, the origin of human tuberculosis has been associated with the Neolithic Demographic Transition, but recent studies point to a much earlier origin. We analyzed the whole genomes of 259 M. tuberculosis complex (MTBC) strains and used this data set to characterize global diversity and t...

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Publisher copy:
10.1038/ng.2744

Authors


Coscolla, M More by this author
Borrell, S More by this author
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Journal:
Nature genetics
Volume:
45
Issue:
10
Pages:
1176-1182
Publication date:
2013-10-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:db431ed3-aaf3-446f-8493-9bb947e66398
Source identifiers:
435212
Local pid:
pubs:435212

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