Presentation of viral antigen controlled by a gene in the major histocompatibility complex.

Journal article

We describe a mutant human cell line (LBL 721.174) that has lost a function required for presentation of intracellular viral antigens with class I molecules of the major histocompatibility complex (MHC), but retains the capacity to present defined epitopes as extracellular peptides. The cell also has a defect in the assembly and expression of class I MHC molecules, which we show can be restored by exposure of the cells to a peptide epitope. This phenotype suggests a defect in the association ...

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Authors: Cerundolo, V; Alexander, J; Anderson, K; Lamb, C; Cresswell, P

• Publication status: Published
• Journal: Nature
• Volume: 345
• Issue: 6274
• Pages: 449-452
• Publication date: 1990-05-01
• DOI: 10.1038/345449a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Cell Line; Antigens, Viral; Oligopeptides; Humans; Antigen-Presenting Cells; Chromosomes, Human, Pair 6; Influenza A virus; Histocompatibility Antigens Class I; Viral Matrix Proteins; Major Histocompatibility Complex; Precipitin Tests