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The structure of hydrogenase-2 from Escherichia coli: implications for H2 -driven proton pumping

Abstract:

Under anaerobic conditions Escherichia coli is able to metabolize molecular hydrogen via the action of several [NiFe]-hydrogenase enzymes. Hydrogenase-2, which is typically present in cells at low levels during anaerobic respiration, is a periplasmic-facing membrane-bound complex that functions as a proton pump to convert energy from H2 oxidation into a proton gradient; consequently, its structure is of great interest. Empirically, the complex consists of a tightly-bound core catalytic module...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1042/BCJ20180053

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Inorganic Chemistry
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Inorganic Chemistry
Finney, AJ More by this author
Lamont, CM More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Inorganic Chemistry
Oxford college:
St Johns College
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Funding agency for:
Armstrong, FA
Publisher:
Portland Press Publisher's website
Journal:
Biochemical Journal Journal website
Volume:
475
Issue:
7
Pages:
1353-1370
Publication date:
2018-04-16
Acceptance date:
2018-03-16
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
Pubs id:
pubs:830412
URN:
uri:db3cf24d-8162-40fc-a79b-52988c27fda6
UUID:
uuid:db3cf24d-8162-40fc-a79b-52988c27fda6
Local pid:
pubs:830412

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