Journal article icon

Journal article

CDX1 is an important molecular mediator of Barrett's metaplasia.

Abstract:

The molecular pathogenesis of Barrett's metaplasia (BM) of the esophagus is poorly understood. The change to an intestinal phenotype occurs on a background of esophagitis due to refluxing acid and bile. CDX1, an important regulator of normal intestinal development, was studied as a potential key molecule in the pathogenesis of BM. CDX1 mRNA and protein were universally expressed in all samples of BM tested but not in normal esophageal squamous or gastric body epithelia. This tissue-specific e...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.0502031102

Authors


Wilding, J More by this author
Bartlett, S More by this author
Warren, BF More by this author
Expand authors...
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
102
Issue:
21
Pages:
7565-7570
Publication date:
2005-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:db21b46e-a66c-4b48-b7f5-8e15ae4a9c06
Source identifiers:
178312
Local pid:
pubs:178312

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP