Journal article icon

Journal article

Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart.

Abstract:

OBJECTIVE: Whole body insulin resistance and diabetes are risk factors for cardiovascular diseases, yet little is known about insulin resistance in the diabetic heart. The aim of this work was to define the insulin response in hearts of the Goto-Kakizaki (GK) rat, a polygenic model of spontaneous type 2 diabetes. METHODS: We measured D[2-3H]glucose uptake before and after insulin stimulation, plus initial steps of the insulin signaling pathway after insulin infusion via the caudal vena cava i...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Desrois, M More by this author
Sidell, RJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Expand authors...
Journal:
Cardiovascular research
Volume:
61
Issue:
2
Pages:
288-296
Publication date:
2004-02-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:db198098-9ad4-4caf-8bf6-2a8ed868f1d5
Source identifiers:
29468
Local pid:
pubs:29468

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP