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A pre-initiation complex at the 3'-end of genes drives antisense transcription independent of divergent sense transcription.

Abstract:

The precise nature of antisense transcripts in eukaryotes such as Saccharomyces cerevisiae remains elusive. Here we show that the 3' regions of genes possess a promoter architecture, including a pre-initiation complex (PIC), which mirrors that at the 5' region and which is much more pronounced at genes with a defined antisense transcript. Remarkably, for genes with an antisense transcript, average levels of PIC components at the 3' region are ∼60% of those at the 5' region. Moreover, at these...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkr1121

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Funding agency for:
Mellor, J
Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
40
Issue:
6
Pages:
2432-2444
Publication date:
2012-03-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:db075a49-3e64-460e-8325-4c4cbd402783
Source identifiers:
216078
Local pid:
pubs:216078

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