Journal article icon

Journal article

Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

Abstract:
A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6- pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by x-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1039/C7OB02289A

Authors


Expand authors...
Bayer Pharma AG More from this funder
Boehringer Ingelheim More from this funder
Canada Foundation for Innovation More from this funder
Eshelman Institute for Innovation More from this funder
Expand funders...
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Organic and Biomolecular Chemistry Journal website
Volume:
15
Issue:
40
Pages:
8655-8660
Publication date:
2017-09-29
Acceptance date:
2017-09-28
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
Pubs id:
pubs:743742
URN:
uri:db05d24a-70af-43e1-809e-dd52f7650529
UUID:
uuid:db05d24a-70af-43e1-809e-dd52f7650529
Local pid:
pubs:743742

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP