- Abstract:
- A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6- pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by x-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 975.5KB)
-
- Publisher copy:
- 10.1039/C7OB02289A
-
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- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Organic and Biomolecular Chemistry Journal website
- Volume:
- 15
- Issue:
- 40
- Pages:
- 8655-8660
- Publication date:
- 2017-09-29
- Acceptance date:
- 2017-09-28
- DOI:
- EISSN:
-
1477-0539
- ISSN:
-
1477-0520
- Pubs id:
-
pubs:743742
- URN:
-
uri:db05d24a-70af-43e1-809e-dd52f7650529
- UUID:
-
uuid:db05d24a-70af-43e1-809e-dd52f7650529
- Local pid:
- pubs:743742
- Copyright holder:
- Royal Society of Chemistry
- Copyright date:
- 2017
- Notes:
- © The Royal Society of Chemistry 2017. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- License:
- CC BY
Journal article
Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety
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AbbVie
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Bayer Pharma AG
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Boehringer Ingelheim
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Canada Foundation for Innovation
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Eshelman Institute for Innovation
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