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Structure-function studies of an engineered scaffold protein derived from stefin A. I: Development of the SQM variant.

Abstract:

Non-antibody scaffold proteins are used for a range of applications, especially the assessment of protein-protein interactions within human cells. The search for a versatile, robust and biologically neutral scaffold previously led us to design STM (stefin A triple mutant), a scaffold derived from the intracellular protease inhibitor stefin A. Here, we describe five new STM-based scaffold proteins that contain modifications designed to further improve the versatility of our scaffold. In a step...

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Publication status:
Published

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Publisher copy:
10.1093/protein/gzq012

Authors


Hoffmann, T More by this author
Stadler, LK More by this author
Buxton, AT More by this author
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Journal:
Protein engineering, design and selection : PEDS
Volume:
23
Issue:
5
Pages:
403-413
Publication date:
2010-05-05
DOI:
EISSN:
1741-0134
ISSN:
1741-0126
URN:
uuid:daf09447-9c00-42dc-8bd0-6918cd032bdc
Source identifiers:
53377
Local pid:
pubs:53377

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